Andy Whyment trained at the Laine Johnson Theatre School in Salford. His first credited part was in Cracker in 1993. He also had minor roles in The Cops, Heartbeat and Where the Heart Is. He attended Salford College of Further Education for a BTEC in Performing Arts, where his real love was singing.
From 1999 until 2000, Whyment appeared as Darren Sinclair-Jones in the BBC comedy The Royle Family. Since 2000, he has played Kirk Sutherland in Coronation Street.
In 2006, Whyment appeared as a contestant in the ITV reality singing competition Soapstar Superstar. He has also appeared as a celebrity darts player on the game show Bullseye in the Bronze Bully Round in one episode. He took part in the 2012 series of Dancing on Ice and was paired up with professional skater Vicky Ogden.